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Nurse Practitioner jobs in South Carolina

129 open Nurse Practitioner positions in South Carolina, drawn from employer listings and updated Sep 1, 2026. Applications go directly to the hiring employer.

001Nurse Practitioner or Physician AssistantMedical University of South Carolina / South CarolinaOpen

002NP/PA - Inpatient PulmonologySpartanburg Regional Healthcare System / SpartanburgOpen

003Nurse Practitioner/Physician Assistant - Oncology (Columbia)Prisma Health / ColumbiaOpen

004Family Nurse PractitionerKidsStreet Clinic (MainStreet Family Care) / South CarolinaOpen

005Nurse Practitioner or Physician Assistant - Psychiatry: Community ClinicMedical University of South Carolina / South CarolinaOpen

006Nurse Practitioner/Physician Assistant- Oncology-Greenville (Faris)Prisma Health / GreenvilleOpen

007Nurse PractitionerYour Health (Health Jobs Nationwide posting) / GreenvilleOpen

008Nurse Practitioner or Physician Assistant |Part Time & PRNPrisma Health Urgent Care / SumterOpen

009Nurse Practitioner IIClemson University / ClemsonOpen

010Nurse Practitioner (Family NP) or Physician Assistant (PA)Coastal Care Partners / BlufftonOpen

011Hospitalist Nurse PractitionerMUSC Health / South CarolinaOpen

012Psychiatric Nurse Practitioner (PMHNP)LifeStance Health / South CarolinaOpen

013Nurse Practitioner or Physician Assistant - Clinical ResearchHeadlands Research / Myrtle BeachOpen

014Advanced Practice Provider NP/PACVS Health / Rock HillOpen

015Nurse Practitioner - Addiction MedicineEasley Comprehensive Treatment Center (CTC) – Acadia Healthcare / EasleyOpen

016Nurse Practitioner or Physician Assistant | EasleyWellStreet Urgent Care / EasleyOpen

017Nurse Practitioner or Physician Assistant | EasleyPrisma Health Urgent Care / EasleyOpen

018Nurse Practitioner or Physician Assistant | SimpsonvillePrisma Health Urgent Care / SimpsonvilleOpen

019NURSE PRACTITIONERCovenant Medical Group / ClintonOpen

020Nurse Practitioner / Physician Assistant - Infectious Disease in Rock Hill, SCSaint Vincent Medical Group / Rock HillOpen

021Urgent Care Nurse Practitioner Role Near Myrtle Beach, SC[Not explicitly provided] / Myrtle BeachOpen

022NP/PA - Internal MedicineSpartanburg Regional Medical Center / SpartanburgOpen

023Nurse Practitioner or Physician Assistant- Primary Care - Optum/Colonial HealthcareOptum/Colonial Healthcare / ColumbiaOpen

024Office Nurse PractitionerColumbia Medical Group / ColumbiaOpen

025Physician Assistant / Nurse Practitioner - Gastroenterology - SumterPrisma Health / SumterOpen

026Nurse Practitioner - Hospitalists - Day ShiftMcLeod Health / FlorenceOpen

027Nurse Practitioner/ Physician Assistant - Hospitalist - PRN - TuomeyPrisma Health / SumterOpen

028Nurse Practitioner or Physician Assistant - Urgent Care near Charlotte, NC - Fort Mill, SCSaint Vincent Medical Group / Fort MillOpen

029Nurse Practitioner/Physician Assistant FT Hilton HeadNovant Health Urgent Care Centers (Novant Health Urgent Care LLC) / Hilton Head IslandOpen

030NP/PA - Urgent Care - Eastside (Part-Time)Spartanburg Regional Healthcare System / SpartanburgOpen