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Registered Nurse jobs in South Carolina

183 open Registered Nurse positions in South Carolina, drawn from employer listings and updated Sep 1, 2026. Applications go directly to the hiring employer.

001Travel Nurse (RN) Home Health (Home Care) Florence, SCEpic Travel Staffing / South CarolinaOpen

002Community Health RNAmedisys / Fort MillOpen

003Registered Nurse (RN) - Physician Practice - Boeing ClinicRoper St. Francis Healthcare / CharlestonOpen

004Experienced Registered Nurse (RN) – Nights – 4th Floor – Acute Care Orthopedic/Spine/Surgical Unit – PMCPelham Medical Center (part of Spartanburg Regional Healthcare System) / SpartanburgOpen

005Physician Office - FT - RN - Florence NeurosurgeryMcLeod Health / FlorenceOpen

006Registered Nurse (RN) - Interventional RadiologyTenet / Piedmont Medical Network - Rock Hill Hospital / Rock HillOpen

007Registered Nurse (RN) - ObservationTenet / Goose CreekOpen

008CMA/LPN/RN - Physician PracticeAnMed / ClemsonOpen

009Registered Nurse – MS/TelemetryHost Healthcare / OrangeburgOpen

010Registered Nurse (RN) - Surgical TraumaTenet / Rock HillOpen

011Registered Nurse (RN)- Oncology- NightsSpartanburg Regional Medical Center / Spartanburg Regional / SpartanburgOpen

012Inpatient Post Surgical Registered NurseHCA Healthcare / SummervilleOpen

013Registered Nurse Home HealthSupplemental Health Care / South CarolinaOpen

014Registered Nurse/RNRCM Health Care Services / OrangeburgOpen

015Registered Nurse – PCU, SIGN-ON BONUS OPPORTUNITY!Beaufort Memorial Hospital / BeaufortOpen

016Registered Nurse (RN)- OncologySpartanburg Regional Medical Center / SpartanburgOpen

017Registered Nurse (RN) – PICUSpartanburg Regional Medical Center / SpartanburgOpen

018Experienced PRN- Registered Nurse (RN) Tier 2 - Days - 3rd Floor - Multi-Specialty Acute Care Tele - PMC | Spartanburg RegionalSpartanburg Regional Healthcare System / SpartanburgOpen

019Experienced Registered Nurse (RN) -Full-time Nights - Acute Care Orthopedic/Spine/Surgical Unit - PMC (Duplicate)Spartanburg Regional Healthcare System / SpartanburgOpen

020Registered Nurse/RNRCM Health Care Services / South CarolinaOpen

021RN, Surgical Trauma, FT Nights; RN, Cardiopulmonary ICU, FT Nights; RN, Neurosurgery, Neuro OR, FT Days; RN, Acute Care General Surgery OR, FT Weekends; RN, Acute Care General Surgery OR, FT Midshift; RN, Cardiovascular OR, FT Days; Certified Surgical Technologist OR, FT DaysPrisma Health Richland Hospital / Prisma Health in the Midlands / South CarolinaOpen

022Registered Nurse, Home Health 10k Sign On Bonus (Eligible)Humana / South CarolinaOpen

023Clinical RN II – Med Surg MBSpartanburg Regional Healthcare System / Spartanburg Regional Medical Center / SpartanburgOpen

024RN, IICU, FT DaysPrisma Health Tuomey Hospital / SumterOpen

025Registered Nurse (RN) Clinical Specialist — Oncology — Tricom & Berkeley HospitalRoper St. Francis Healthcare / North CharlestonOpen

026Registered Nurse (RN) - Hematology / Oncology Med SurgHCA Healthcare Trident Hospital / FlorenceOpen

027Registered Nurse (RN) - Labor and DeliveryHCA Healthcare Summerville Hospital / BlufftonOpen

028Registered Nurse (RN) - Labor and DeliveryHCA Healthcare Summerville Hospital / BeaufortOpen

029Registered Nurse (RN) - Hematology / Oncology Med SurgHCA Healthcare Trident Hospital / BeaufortOpen

030Registered Nurse (RN) - New GraduateHCA Healthcare Trident Hospital / Goose CreekOpen